5/1/2025
Last update
5/1/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 1 softgel
Amount Per Serving
%DV
Calories
9
Calories from Fat
7
Total Fat
1 g
1%¹
Saturated Fat
0 g
0%¹
Unsaturated Fat
0.5 g
Trans Fat
0 g
Total Omega-3 Fatty Acids
640 mg
+
DHA (Docosahexanoic Acid)
480 mg
EPA (Eicosapentaenoic Acid)
104 mg
Other Omega-3s
56 mg
Top Medical Research Studies
9
DHA aids post-heart attack recovery
We explored the effects of docosahexaenoic acid (DHA) on heart attack recovery in rats. The study aimed to understand how DHA, alongside eicosapentaenoic acid (EPA), can influence heart failure following myocardial infarction (MI).
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Read More
9
We investigated how eicosapentaenoic acid (EPA) may help improve heart health after a heart attack. In our study, we induced myocardial infarction (MI) in male rats by ligating their coronary artery. Some of these rats received daily treatment with EPA, while others did not, allowing us to compare the effects.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
Read More
9
DHA supports heart recovery post-MI
We investigated how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences recovery following a heart attack (MI) in the context of dietary fat intake. The study began by feeding mice with safflower oil (rich in omega-6 fatty acids) for 12 weeks, followed by DHA supplementation for another 8 weeks before inducing a heart attack.
Through this process, we observed that the early intake of safflower oil led to heightened inflammation, delaying the body’s ability to heal. However, when we supplemented with DHA, we noted a favorable shift. DHA increased the levels of specialized proresolving mediators (SPMs) that help the body resolve inflammation. These mediators seemed to counteract the negative effects of safflower oil by enhancing mechanisms in both the heart and kidneys critical for recovery post-MI.
Additionally, DHA contributed to an increase in resolving macrophages, which play a vital role in repairing the heart, and it also elevated T regulatory cells in the heart tissue during chronic heart failure. This might suggest that transitioning from a diet high in omega-6 fatty acids to one rich in omega-3s like DHA could improve outcomes after heart attacks.
Overall, while excessive safflower oil intake worsens inflammation and affects heart recovery, DHA promotes a healthier resolving phase, supporting better heart and kidney function in the aftermath of a heart attack.
Through this process, we observed that the early intake of safflower oil led to heightened inflammation, delaying the body’s ability to heal. However, when we supplemented with DHA, we noted a favorable shift. DHA increased the levels of specialized proresolving mediators (SPMs) that help the body resolve inflammation. These mediators seemed to counteract the negative effects of safflower oil by enhancing mechanisms in both the heart and kidneys critical for recovery post-MI.
Additionally, DHA contributed to an increase in resolving macrophages, which play a vital role in repairing the heart, and it also elevated T regulatory cells in the heart tissue during chronic heart failure. This might suggest that transitioning from a diet high in omega-6 fatty acids to one rich in omega-3s like DHA could improve outcomes after heart attacks.
Overall, while excessive safflower oil intake worsens inflammation and affects heart recovery, DHA promotes a healthier resolving phase, supporting better heart and kidney function in the aftermath of a heart attack.
Read More
Most Useful Reviews
10
Prevents heart problems
Excellent! Omega 3 provides numerous benefits such as preventing heart diseases and reducing the likelihood of heart attack. It enhances brain function, eyesight, and skin health, while supporting the immune system and mitigating feelings of depression and anxiety.
Read More
9
Supports heart health
A great quality fish oil with excellent ingredients. The benefits for heart health are remarkable, particularly in reducing the risk of heart attack.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.8
- All Researches
9
DHA aids post-heart attack recovery
We explored the effects of docosahexaenoic acid (DHA) on heart attack recovery in rats. The study aimed to understand how DHA, alongside eicosapentaenoic acid (EPA), can influence heart failure following myocardial infarction (MI).
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Read More
9
DHA supports heart recovery post-MI
We investigated how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences recovery following a heart attack (MI) in the context of dietary fat intake. The study began by feeding mice with safflower oil (rich in omega-6 fatty acids) for 12 weeks, followed by DHA supplementation for another 8 weeks before inducing a heart attack.
Through this process, we observed that the early intake of safflower oil led to heightened inflammation, delaying the body’s ability to heal. However, when we supplemented with DHA, we noted a favorable shift. DHA increased the levels of specialized proresolving mediators (SPMs) that help the body resolve inflammation. These mediators seemed to counteract the negative effects of safflower oil by enhancing mechanisms in both the heart and kidneys critical for recovery post-MI.
Additionally, DHA contributed to an increase in resolving macrophages, which play a vital role in repairing the heart, and it also elevated T regulatory cells in the heart tissue during chronic heart failure. This might suggest that transitioning from a diet high in omega-6 fatty acids to one rich in omega-3s like DHA could improve outcomes after heart attacks.
Overall, while excessive safflower oil intake worsens inflammation and affects heart recovery, DHA promotes a healthier resolving phase, supporting better heart and kidney function in the aftermath of a heart attack.
Through this process, we observed that the early intake of safflower oil led to heightened inflammation, delaying the body’s ability to heal. However, when we supplemented with DHA, we noted a favorable shift. DHA increased the levels of specialized proresolving mediators (SPMs) that help the body resolve inflammation. These mediators seemed to counteract the negative effects of safflower oil by enhancing mechanisms in both the heart and kidneys critical for recovery post-MI.
Additionally, DHA contributed to an increase in resolving macrophages, which play a vital role in repairing the heart, and it also elevated T regulatory cells in the heart tissue during chronic heart failure. This might suggest that transitioning from a diet high in omega-6 fatty acids to one rich in omega-3s like DHA could improve outcomes after heart attacks.
Overall, while excessive safflower oil intake worsens inflammation and affects heart recovery, DHA promotes a healthier resolving phase, supporting better heart and kidney function in the aftermath of a heart attack.
Read More
9
We set out to explore how docosahexaenoic acid (DHA), a beneficial omega-3 fatty acid found in fish oil and seaweed, might play a role in heart health, particularly after a heart attack. Our findings stemmed from experiments on both isolated heart cells under low oxygen conditions and live mice experiencing myocardial infarction (MI), which is the medical term for a heart attack.
The results were promising. We observed that DHA not only improved cell survival in stressed heart cells but also minimized damage in mice following a heart attack. Specifically, we noted a reduction in heart injury and a boost in heart function, highlighting DHA's potential as a protective agent.
Importantly, we found that DHA enhances autophagy—a natural process that cleans out damaged cells—by activating specific signaling pathways in the body. We established that in both our test models, the presence of DHA led to less cell death and richer heart function recovery. However, when we inhibited the autophagy process in experiments, the protective advantages of DHA were lost, underscoring its reliance on this cell-cleaning mechanism.
Our study indicates that DHA may serve as a valuable aid in healing the heart after a heart attack by promoting processes that protect against cell damage. Balancing scientific insight with real-world implications offers a promising avenue for heart health strategies, especially for those recovering from myocardial infarction.
The results were promising. We observed that DHA not only improved cell survival in stressed heart cells but also minimized damage in mice following a heart attack. Specifically, we noted a reduction in heart injury and a boost in heart function, highlighting DHA's potential as a protective agent.
Importantly, we found that DHA enhances autophagy—a natural process that cleans out damaged cells—by activating specific signaling pathways in the body. We established that in both our test models, the presence of DHA led to less cell death and richer heart function recovery. However, when we inhibited the autophagy process in experiments, the protective advantages of DHA were lost, underscoring its reliance on this cell-cleaning mechanism.
Our study indicates that DHA may serve as a valuable aid in healing the heart after a heart attack by promoting processes that protect against cell damage. Balancing scientific insight with real-world implications offers a promising avenue for heart health strategies, especially for those recovering from myocardial infarction.
Read More
9
We explored the role of eicosapentaenoic acid (EPA) in heart attack recovery, particularly its effect on restoring blood flow during ST-elevation myocardial infarction (STEMI). Our focus was on understanding whether higher levels of EPA relative to arachidonic acid could lead to faster recovery and better outcomes for patients experiencing this type of heart attack.
The study revealed that patients with elevated EPA levels indeed showed quicker restoration of coronary blood flow. This is promising, as efficient blood flow restoration is critical in minimizing heart damage during a heart attack. However, it’s essential to note that the effectiveness of EPA may vary based on other treatments the patients are receiving.
These findings suggest a positive link between EPA and heart attack recovery, but further investigation is necessary to determine the best approaches for integrating EPA into treatment protocols. Ultimately, while we observed encouraging results, the interplay between dietary interventions and other medical treatments warrants additional research.
The study revealed that patients with elevated EPA levels indeed showed quicker restoration of coronary blood flow. This is promising, as efficient blood flow restoration is critical in minimizing heart damage during a heart attack. However, it’s essential to note that the effectiveness of EPA may vary based on other treatments the patients are receiving.
These findings suggest a positive link between EPA and heart attack recovery, but further investigation is necessary to determine the best approaches for integrating EPA into treatment protocols. Ultimately, while we observed encouraging results, the interplay between dietary interventions and other medical treatments warrants additional research.
Read More
9
We explored how eicosapentaenoic acid (EPA) and its metabolites can protect heart cells during a heart attack, specifically focusing on a laboratory model for ischemic injury. Our investigation centered on a specific receptor found in heart cells, known as the Free Fatty Acid Receptor 4 (Ffar4).
In our experiments, cardiac myocytes, or heart cells, were exposed to a controlled environment mimicking conditions of reduced blood flow followed by reoxygenation, essentially simulating a heart attack scenario. Applying an Ffar4 agonist, TUG-891, along with EPA-derived components like 18-hydroxyeicosapentaenoic acid (18-HEPE) and resolvin E1 (RvE1), we observed a significant reduction in harmful reactive oxygen species and heart cell death.
Notably, blocking the ChemR23 receptor with a specific antagonist negated the protective effects we noted from these treatments. This finding highlights that Ffar4 and ChemR23 work together in heart cells to defend against the damage that occurs after ischemic injury.
Overall, our data reinforce the idea that eicosapentaenoic acid has beneficial roles in protecting heart cells from ischemia, meriting further exploration as a potential therapeutic in heart attack management.
In our experiments, cardiac myocytes, or heart cells, were exposed to a controlled environment mimicking conditions of reduced blood flow followed by reoxygenation, essentially simulating a heart attack scenario. Applying an Ffar4 agonist, TUG-891, along with EPA-derived components like 18-hydroxyeicosapentaenoic acid (18-HEPE) and resolvin E1 (RvE1), we observed a significant reduction in harmful reactive oxygen species and heart cell death.
Notably, blocking the ChemR23 receptor with a specific antagonist negated the protective effects we noted from these treatments. This finding highlights that Ffar4 and ChemR23 work together in heart cells to defend against the damage that occurs after ischemic injury.
Overall, our data reinforce the idea that eicosapentaenoic acid has beneficial roles in protecting heart cells from ischemia, meriting further exploration as a potential therapeutic in heart attack management.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Prevents heart problems
Excellent! Omega 3 provides numerous benefits such as preventing heart diseases and reducing the likelihood of heart attack. It enhances brain function, eyesight, and skin health, while supporting the immune system and mitigating feelings of depression and anxiety.
Read More
9
Supports heart health
A great quality fish oil with excellent ingredients. The benefits for heart health are remarkable, particularly in reducing the risk of heart attack.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Dinu M, Sofi F, Lotti S, Colombini B, Mattioli AV, et al. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis. Eur J Prev Cardiol. 2024;31:1863. 10.1093/eurjpc/zwae184
- Le VT, Knight S, Watrous JD, Najhawan M, Dao K, et al. Higher docosahexaenoic acid levels lower the protective impact of eicosapentaenoic acid on long-term major cardiovascular events. Front Cardiovasc Med. 2023;10:1229130. 10.3389/fcvm.2023.1229130
- Luo X, Liu M, Wang S, Chen Y, Bao X, et al. Combining metabolomics and OCT to reveal plasma metabolic profiling and biomarkers of plaque erosion and plaque rupture in STEMI patients. Int J Cardiol. 2023;390:131223. 10.1016/j.ijcard.2023.131223
- Myhre PL, Berge T, Kalstad AA, Tveit SH, Laake K, et al. Omega-3 fatty acid supplements and risk of atrial fibrillation and 'micro-atrial fibrillation': A secondary analysis from the OMEMI trial. Clin Nutr. 2023;42:1657. 10.1016/j.clnu.2023.07.002
- Chiusolo S, Bork CS, Gentile F, Lundbye-Christensen S, Harris WS, et al. Adipose tissue n-3/n-6 fatty acids ratios versus n-3 fatty acids fractions as predictors of myocardial infarction. Am Heart J. 2023;262:38. 10.1016/j.ahj.2023.03.019
- Bork CS, Lundbye-Christensen S, Venø SK, Lasota AN, Tjønneland A, et al. Intake of marine and plant-derived n-3 fatty acids and development of atherosclerotic cardiovascular disease in the Danish Diet, Cancer and Health cohort. Eur J Nutr. 2023;62:1389. 10.1007/s00394-022-03081-w
- Park GH, Cho JH, Lee D, Kim Y. Association between Seafood Intake and Cardiovascular Disease in South Korean Adults: A Community-Based Prospective Cohort Study. Nutrients. 2022;14. 10.3390/nu14224864
- Bassuk SS, Manson JE. Marine omega-3 fatty acid supplementation and prevention of cardiovascular disease: update on the randomized trial evidence. Cardiovasc Res. 2023;119:1297. 10.1093/cvr/cvac172
- Alfaddagh A, Kapoor K, Dardari ZA, Bhatt DL, Budoff MJ, et al. Omega-3 fatty acids, subclinical atherosclerosis, and cardiovascular events: Implications for primary prevention. Atherosclerosis. 2022;353:11. 10.1016/j.atherosclerosis.2022.06.1018
- Sunagawa Y, Katayama A, Funamoto M, Shimizu K, Shimizu S, et al. The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats. J Nutr Biochem. 2022;106:109031. 10.1016/j.jnutbio.2022.109031
- Halade GV, Kain V, De La Rosa X, Lindsey ML. Metabolic transformation of fat in obesity determines the inflammation resolving capacity of splenocardiac and cardiorenal networks in heart failure. Am J Physiol Heart Circ Physiol. 2022;322:H953. 10.1152/ajpheart.00684.2021
- Shi Y, Li H, Wu T, Wang Q, Zhu Q, et al. Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway. Oxid Med Cell Longev. 2022;2022:1509421. 10.1155/2022/1509421
- Wang CP, Lee CC, Wu DY, Chen SY, Lee TM. Differential effects of EPA and DHA on PPARγ-mediated sympathetic innervation in infarcted rat hearts by GPR120-dependent and -independent mechanisms. J Nutr Biochem. 2022;103:108950. 10.1016/j.jnutbio.2022.108950
- Myhre PL, Kalstad AA, Tveit SH, Laake K, Schmidt EB, et al. Changes in eicosapentaenoic acid and docosahexaenoic acid and risk of cardiovascular events and atrial fibrillation: A secondary analysis of the OMEMI trial. J Intern Med. 2022;291:637. 10.1111/joim.13442
- Pertiwi K, Küpers LK, de Goede J, Zock PL, Kromhout D, et al. Dietary and Circulating Long-Chain Omega-3 Polyunsaturated Fatty Acids and Mortality Risk After Myocardial Infarction: A Long-Term Follow-Up of the Alpha Omega Cohort. J Am Heart Assoc. 2021;10:e022617. 10.1161/JAHA.121.022617
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
- Yamada R, Uematsu M, Nakamura T, Kobayashi T, Horikoshi T, et al. Elevated eicosapentaenoic acid to arachidonic acid ratio and rapid coronary blood flow restoration in ST-elevation myocardial infarction. Hellenic J Cardiol. 2025. 10.1016/j.hjc.2025.01.003
- Puccini SJ, Healy CL, Harsch BA, Ahmed AR, Shearer GC, et al. A Cell Autonomous Free fatty acid receptor 4 - ChemR23 Signaling Cascade Protects Cardiac Myocytes from Ischemic Injury. bioRxiv. 2025. 10.1101/2024.11.26.625260
- Miyauchi K, Iwata H, Nishizaki Y, Inoue T, Hirayama A, et al. Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid (RESPECT-EPA). Circulation. 2024;150:425. 10.1161/CIRCULATIONAHA.123.065520
- Burger PM, Bhatt DL, Dorresteijn JAN, Koudstaal S, Mosterd A, et al. Effects of icosapent ethyl according to baseline residual risk in patients with atherosclerotic cardiovascular disease: results from REDUCE-IT. Eur Heart J Cardiovasc Pharmacother. 2024;10:488. 10.1093/ehjcvp/pvae030
- Szarek M, Bhatt DL, Miller M, Brinton EA, Jacobson TA, et al. Lipoprotein(a) Blood Levels and Cardiovascular Risk Reduction With Icosapent Ethyl. J Am Coll Cardiol. 2024;83:1529. 10.1016/j.jacc.2024.02.016
- Sabbour H, Bhatt DL, Elhenawi Y, Aljaberi A, Bennani L, et al. A Practical Approach to the Management of Residual Cardiovascular Risk: United Arab Emirates Expert Consensus Panel on the Evidence for Icosapent Ethyl and Omega-3 Fatty Acids. Cardiovasc Drugs Ther. 2024. 10.1007/s10557-023-07519-z
- Bernhard B, Heydari B, Abdullah S, Francis SA, Lumish H, et al. Effect of six month's treatment with omega-3 acid ethyl esters on long-term outcomes after acute myocardial infarction: The OMEGA-REMODEL randomized clinical trial. Int J Cardiol. 2024;399:131698. 10.1016/j.ijcard.2023.131698
- Borghi C, Bragagni A. Clinical results and mechanism of action of icosapent ethyl. Eur Heart J Suppl. 2023;25:B37. 10.1093/eurheartjsupp/suad088
- Rabbat MG, Lakshmanan S, Benjamin MM, Doros G, Kinninger A, et al. Benefit of icosapent ethyl on coronary physiology assessed by computed tomography angiography fractional flow reserve: EVAPORATE-FFRCT. Eur Heart J Cardiovasc Imaging. 2023;24:866. 10.1093/ehjci/jead063
- Kobara M, Shiraishi T, Noda K, Toba H, Nakata T. Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats. J Cardiovasc Transl Res. 2023;16:816. 10.1007/s12265-023-10363-z
